ABSTRACT
The ApoB/ApoA-I ratio reflects the balance between pro- and anti-atherogenic particles, all of which contain cholesterol. The ApoB/A ratio is valid in both genders of all ages and is independent of the lipid levels and phenotypes. This study has been designed to investigate the association between the ratio of apolipoprotein B (apo B)/ apolipoprotein A1 (apo A1) and HDL-C with severity of coronary artery disease in patients with and without type 2 diabetes mellitus.METHODSThe present case control study was carried out in departments of Cardiology and Biochemistry, Vinayaka Missions Hospital, Salem. Fasting blood samples have been collected from 109 CAD patients and 71 control subjects. Serum lipids were measured enzymatically, ApoA-I and Apo B were analysed by immunoturbidimetric method. The study was approved by ethics committee and informed consent was obtained.RESULTSIn our study, Apo A-1 level was significantly low (1.187±0.20) and Apo B was found to be significantly high (1.64±0.62) in CAD with diabetes subjects, when compared to CAD without diabetes. HDL level was found to be significantly lowered in CAD patients. A significant positive association was observed between ApoA-1 and lipid parameters in CAD subjects with HDL-C at (p= 0.00).CONCLUSIONSApo B/Apo A1 ratio may be a healthier forecaster than conventional lipid markers to explore the severity of CAD. This study suggests that instead of measurement of lipid profiles alone, a better indicator apo B, A-I and B/A-I ratio measurement, which in turn highlights the cholesterol balance, can reduce the delay in the recognition of CAD.
ABSTRACT
The increased incidence of coronary artery disease (CAD) in Type 2 Diabetes mellitus is not fully explained by the conventional risk factors. Our aim was to determine the association of biomarkers, high sensitive CRP and anticardiolipin antibody (acL) with severity of coronary artery disease in patients with and without type 2 DM. In our study, hsCRP level was significantly high in CAD with DM and found to be positively correlated with severity (p<0.01) while anticardiolipin antibody does not show any significant change among the two groups. Our study concluded that increased risk of CAD in type 2 DM patients is not only because of dyslipidemia but inflammatory events also play a major role. hsCRP was found to be a valuable predictor for CAD in type 2 DM.
ABSTRACT
The increasing disease burden due to coronary artery disease (CAD) can be minimized by an early detection using a valid risk factor. Aim of this study was to determine the level of apolipoprotein AI(ApoAI), apolipoprotein B(ApoB) and ApoB/ApoAI ratio in CAD patients with or without type II diabetes mellitus(DM) and to analyze whether these parameters can be used as a more accurate lipid risk factor than the conventional ones. Fasting blood samples were collected from angiographically determined coronary artery disease patients with or without type II DM and control subjects. Serum total cholesterol (TC), triglycerides (TG),and high density lipoprotein (HDL-C)were measured enzymatically ,low density lipoprotein (LDL-C) was determined using Friedewald's formula ,Apo AI and Apo B were analyzed by immunoturbidimetric method. Plasma values of total cholesterol, triglycerides (TG), low density lipoprotein (LDL) cholesterol, were not significantly different in the groups with normal coronary arteries and CAD. Level of ApoB was significantly higher and the level of Apo AI was significantly lower in CAD patients when compared to normal coronary artery group. In the study, ratio of Apo B to Apo AI (Apo B/ Apo AI) was found to be markedly high in CAD patients ( p<0.001) when compared to the control . As the ratio covers both atherogenic and antiatherogenic lipid risk factor, it can be used as a better predictor than conventional risk factor.